Endocrine Abstracts

It has been reported that Ang II induces the growth of MCF-7 breast cancer cells (Muscella et al., J Endocrinol 173, 315-323, 2002). Here we have examined the signalling pathways evoked by Ang II in MCF-7. Ang II did not change the concentration of intracellular calcium but induced the cytosol-to-membrane translocation of atypical protein kinase C zeta (PKC-zeta). Ang II dose-dependently induced c-fos (mRNA and protein) and enhanced the phosphorylation state of extracellular s...